Antiphospholipid syndrome: interpretation of laboratory data
نویسندگان
چکیده
منابع مشابه
Laboratory Diagnostics of Antiphospholipid Syndrome.
Diagnosis of antiphospholipid syndrome (APS) lies in the recognition of antiphospholipid antibodies (aPL). As standardization of tests for the detection of aPL is far from being optimal and reference material is not available, inappropriate diagnoses of APS are not unusual. In the last few years, the concept of triple test positivity has emerged as a useful tool to identify patients with APS. C...
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Th e antiphospholipid syndrome (APS) was fi rst described in 1986. Th e original association of this hypercoagulable state with anticardiolipin antibodies (aCL) resulted from the synthesis of evidence stemming from laboratory fi ndings in systemic lupus erythematosus (SLE), ie, the frequent occurrence of false-positive VDRL tests and the paradoxical observation of the so-called “lupus anticoagu...
متن کاملLaboratory detection of the antiphospholipid syndrome via calibrated automated thrombography.
Lupus anticoagulants (LAC) consist of antiphospholipid antibodies, detected via their anticoagulant properties in vitro. Strong LAC relate to thromboembolic events, a hallmark of the antiphospholipid syndrome. We have analyzed whether detection of this syndrome would benefit from thrombin generation measurements. Therefore, calibrated automated thrombography was done in normal plasma (n = 30) a...
متن کاملAntiphospholipid syndrome: association between laboratory tests and clinical practice.
Antiphospholipid antibodies are a wide and heterogeneous group of immunoglobulins, whose presence inpatients with arterial and venous thrombosis, and obstetrical complications defines the antiphospholipid syndrome. We systematically reviewed published articles on this syndrome to investigate the association between thrombosis and the most common antiphospholipid antibodies. Lupus anticoagulants...
متن کاملLaboratory Diagnosis of Antiphospholipid Antibodies
Antiphospholipid antibodies may be associated with venous thromboembolism and/or arterial thromboses or miscarriages; their heterogeneity complicates the laboratory diagnosis. For a long time, they were believed to be directed against anionic phospholipids. More recently, it has been demonstrated that these antibodies are directed at plasma proteins bound most of the time to a phos-pholipid sur...
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ژورنال
عنوان ژورنال: Journal of Thrombosis and Haemostasis
سال: 2011
ISSN: 1538-7933
DOI: 10.1111/j.1538-7836.2010.04151.x